Activating Compound | Comment | Organism | Structure |
---|---|---|---|
H2O2 | the kinase activity of biliverdin reductase is stimulated by generators of free radicals such as H2O2 | Homo sapiens | |
sodium arsenite | the kinase activity of biliverdin reductase is stimulated by generators of free radicals such as sodium arsenite | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
biliverdin + ? | Homo sapiens | - |
bilirubin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
biliverdin + ? | - |
Homo sapiens | bilirubin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
biliverdin reductase | human biliverdin reductase is a dual-specificity kinase (Ser/Thr and Tyr) | Homo sapiens |
BVR | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | human biliverdin reductase is an upstream activator of the insulin/insulin growth factor-1 and mitogen-activated protein kinase signaling pathways, and also a basic-leucine-zipper DNA/chromatin-binding transcription factor, an activator and anchor protein for translocation of protein kinase C betaII and zeta isozymes within cell compartments, and a kinase kinase for their activation. Biliverdin reductase is essential for mitogen-activated protein kinase-extracellular signal-regulated kinase 1/2-eukaryotic-like protein kinase signaling and has been identified as the cytoplasm-nuclear heme transporter of extracellular signal-regulated kinase 1/2 and hematin | Homo sapiens |